| Gene Information | |
|---|---|
| Gene Name | FZR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 496 |
| Protein Names | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000105325 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UM11 |
| Gene Card | FZR1 |
| Uniprot ID | Q9UM11 |
| Pfam | PF12894; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.446442215) |
| Ortholog in Animals | Alpaca_ FZR1 ( ortholog_one2one ) Dog_ FZR1 ( ortholog_one2one ) GuineaPig_ FZR1 ( ortholog_one2one ) Macaque_ FZR1 ( ortholog_one2one ) Mouse_ Fzr1 ( ortholog_one2one ) Pig_ FZR1 ( ortholog_one2one ) Rat_ Fzr1 ( ortholog_one2one ) Rabbit_ FZR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDC20, CDC20B |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. {ECO:0000269|PubMed:12797865}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.357920(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UI9 (EM 3.60A ) 5L9T (EM 6.40A ) 5L9U (EM 6.40A ) 7QE7 (EM 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 2]: Nucleus.; [Isoform 3]: Cytoplasm. |
| Mouse PG classification | NA |
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