| Gene Information | |
|---|---|
| Gene Name | CHRM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 466 |
| Protein Names | Muscarinic acetylcholine receptor M2 |
| Target Name | muscarinic acetylcholine receptor |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000181072 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08172 |
| Gene Card | CHRM2 |
| Uniprot ID | P08172 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.727748548) |
| Ortholog in Animals | Alpaca_ CHRM2 ( ortholog_one2one ) Dog_ CHRM2 ( ortholog_one2one ) GuineaPig_ CHRM2 ( ortholog_one2one ) Macaque_ CHRM2 ( ortholog_one2one ) Mouse_ Chrm2 ( ortholog_one2one ) Pig_ CHRM2 ( ortholog_one2one ) Rat_ Chrm2 ( ortholog_one2one ) Rabbit_ CHRM2 ( ortholog_one2one ) |
| Ohnologs | CHRM1, CHRM5, CHRM3 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, GPR161, DRD5, TAAR2 |
| Tissue | heart, gall.bladder, left.atrium, left.ventricle, mitral.valve, pulmonary.valve, smooth.muscle, sigmoid.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3UON (X-ray 3.00A ) 4MQS (X-ray 3.50A ) 4MQT (X-ray 3.70A ) 5YC8 (X-ray 2.50A ) 5ZK3 (X-ray 2.60A ) 5ZK8 (X-ray 3.00A ) 5ZKB (X-ray 2.95A ) 5ZKC (X-ray 2.30A ) 6OIK (EM 3.60A ) 6U1N (EM 4.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}; Multi-pass membrane protein {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733}. Postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}. |
| Mouse PG classification | NA |
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