| Gene Information | |
|---|---|
| Gene Name | FZD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | Frizzled-6 (Fz-6) (hFz6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000164930 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O60353 |
| Gene Card | FZD6 |
| Uniprot ID | O60353 |
| Pfam | PF01534; PF01392 |
| In ASD | no |
| Allosteric Prediction | no (-0.135688329) |
| Ortholog in Animals | Alpaca_ FZD6 ( ortholog_one2one ) Dog_ FZD6 ( ortholog_one2one ) GuineaPig_ FZD6 ( ortholog_one2one ) Macaque_ FZD6 ( ortholog_one2one ) Mouse_ Fzd6 ( ortholog_one2one ) Pig_ FZD6 ( ortholog_one2one ) Rat_ Fzd6 ( ortholog_one2one ) Rabbit_ FZD6 ( ortholog_one2one ) |
| Ohnologs | FZD3 |
| Paralogs | SFRP5, SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD8, SMO, FZD1, SFRP2, FZD4, FZD3 |
| Tissue | NA |
| Tissue Specificity | Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs827528 rs80216383 rs61753730 rs3808553 rs142694816 rs150760762 rs151339003 rs767273753 rs79408516 rs116195528 rs12549394 |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| Mouse PG classification | NA |
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