| Gene Information | |
|---|---|
| Gene Name | FZD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 666 |
| Protein Names | Frizzled-3 (Fz-3) (hFz3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000104290 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPG1 |
| Gene Card | FZD3 |
| Uniprot ID | Q9NPG1 |
| Pfam | PF01534; PF01392 |
| In ASD | no |
| Allosteric Prediction | no (-0.225328297) |
| Ortholog in Animals | Alpaca_ FZD3 ( ortholog_one2one ) Dog_ FZD3 ( ortholog_one2one ) GuineaPig_ FZD3 ( ortholog_one2one ) Macaque_ FZD3 ( ortholog_one2one ) Mouse_ Fzd3 ( ortholog_one2one ) Pig_ FZD3 ( ortholog_one2one ) Rat_ Fzd3 ( ortholog_one2one ) Rabbit_ FZD3 ( ortholog_one2one ) |
| Ohnologs | FZD6, FZD2, FZD7 |
| Paralogs | SFRP5, SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs140115204 rs757589666 rs199839949 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}. |
| Mouse PG classification | NA |
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