| Gene Information | |
|---|---|
| Gene Name | MANBA |
| Organism | Homo sapiens (Human) |
| Gene Length | 879 |
| Protein Names | Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000109323 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O00462 |
| Gene Card | MANBA |
| Uniprot ID | O00462 |
| Pfam | PF02836; PF17753; PF17786 |
| In ASD | no |
| Allosteric Prediction | no (-0.809625973) |
| Ortholog in Animals | Alpaca_ MANBA ( ortholog_one2one ) Dog_ MANBA ( ortholog_one2one ) GuineaPig_ MANBA ( ortholog_one2one ) Macaque_ MANBA ( ortholog_one2one ) Mouse_ Manba ( ortholog_one2one ) Pig_ MANBA ( ortholog_one2one ) Rat_ Manba ( ortholog_one2one ) Rabbit_ MANBA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GUSB |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Detected in pancreas, kidney and placenta, ands at lower levels in liver, lung, brain, heart and muscle. {ECO:0000269|PubMed:9384606}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs374377679 rs227368 rs227368 rs121434334 rs2866413 |
| Subcellular location [CC] | Lysosome {ECO:0000305}. |
| Mouse PG classification | LPG |
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