| Gene Information | |
|---|---|
| Gene Name | FZD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000104290 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O00144 |
| Gene Card | FZD9 |
| Uniprot ID | O00144 |
| Pfam | PF01534; PF01392 |
| In ASD | no |
| Allosteric Prediction | no (-0.225328297) |
| Ortholog in Animals | Alpaca_ FZD3 ( ortholog_one2one ) Dog_ FZD3 ( ortholog_one2one ) GuineaPig_ FZD3 ( ortholog_one2one ) Macaque_ FZD3 ( ortholog_one2one ) Mouse_ Fzd3 ( ortholog_one2one ) Pig_ FZD3 ( ortholog_one2one ) Rat_ Fzd3 ( ortholog_one2one ) Rabbit_ FZD3 ( ortholog_one2one ) |
| Ohnologs | FZD6, FZD2, FZD7 |
| Paralogs | SFRP5, SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD4 |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850). {ECO:0000269|PubMed:27509850}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein {ECO:0000255}. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}. |
| Mouse PG classification | NA |
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