| Gene Information | |
|---|---|
| Gene Name | FZD10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 581 |
| Protein Names | Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350) |
| Target Name | frizzled-10 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000111432 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULW2 |
| Gene Card | FZD10 |
| Uniprot ID | Q9ULW2 |
| Pfam | PF01534; PF01392 |
| In ASD | no |
| Allosteric Prediction | no (-0.793458566) |
| Ortholog in Animals | Alpaca_ FZD10 ( ortholog_one2one ) Dog_ FZD10 ( ortholog_one2one ) GuineaPig_ FZD10 ( ortholog_one2one ) Macaque_ FZD10 ( ortholog_one2one ) Mouse_ Fzd10 ( ortholog_one2one ) Pig_ FZD10 ( ortholog_one2one ) Rat_ Fzd10 ( ortholog_one2one ) |
| Ohnologs | FZD5, FZD4, FZD9 |
| Paralogs | SFRP5, SFRP1, FZD5, FZD2, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD4, FZD3 |
| Tissue | NA |
| Tissue Specificity | Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. {ECO:0000269|PubMed:10448064}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:19188438}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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