| Gene Information | |
|---|---|
| Gene Name | FYN |
| Organism | Homo sapiens (Human) |
| Gene Length | 537 |
| Protein Names | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) |
| Target Name | fyn tyrosine protein kinase |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000010810 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P06241 |
| Gene Card | FYN |
| Uniprot ID | P06241 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (1.218606476) |
| Ortholog in Animals | Alpaca_ FYN ( ortholog_one2one ) Dog_ FYN ( ortholog_one2one ) GuineaPig_ FYN ( ortholog_one2one ) Macaque_ FYN ( ortholog_one2one ) Mouse_ Fyn ( ortholog_one2one ) Pig_ FYN ( ortholog_one2one ) Rat_ Fyn ( ortholog_one2one ) Rabbit_ FYN ( ortholog_one2one ) |
| Ohnologs | HCK, YES1, SRC, FGR, LCK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, PTK6 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.045004(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A0N (NMR - ) 1AOT (NMR - ) 1AOU (NMR - ) 1AVZ (X-ray 3.00A ) 1AZG (NMR - ) 1EFN (X-ray 2.50A ) 1FYN (X-ray 2.30A ) 1G83 (X-ray 2.60A ) 1M27 (X-ray 2.50A ) 1NYF (NMR - ) 1NYG (NMR - ) 1SHF (X-ray 1.90A ) 1ZBJ (NMR - ) 2DQ7 (X-ray 2.80A ) 2MQI (NMR - ) 2MRJ (NMR - ) 2MRK (NMR - ) 3H0F (X-ray 2.61A ) 3H0H (X-ray 1.76A ) 3H0I (X-ray 2.20A ) 3UA6 (X-ray 1.85A ) 3UA7 (X-ray 1.50A ) 4D8D (X-ray 2.52A ) 4EIK (X-ray 1.60A ) 4U17 (X-ray 1.99A ) 4U1P (X-ray 1.40A ) 4ZNX (X-ray 2.10A ) 5ZAU (NMR - ) 6EDF (X-ray 1.40A ) 6IPY (X-ray 1.34A ) 6IPZ (X-ray 1.58A ) 7A2J (X-ray 1.50A ) 7A2K (X-ray 1.50A ) 7A2L (X-ray 1.90A ) 7A2M (X-ray 1.50A ) 7A2N (X-ray 1.40A ) 7A2O (X-ray 0.94A ) 7A2P (X-ray 0.90A ) 7A2Q (X-ray 0.94A ) 7A2R (X-ray 1.05A ) 7A2S (X-ray 1.02A ) 7A2T (X-ray 1.22A ) 7A2U (X-ray 1.70A ) 7A2V (X-ray 1.81A ) 7A2W (X-ray 0.99A ) 7A2X (X-ray 0.92A ) 7A2Y (X-ray 0.97A ) 7A2Z (X-ray 1.14A ) |
| DBSNP | rs1801121 rs28763975 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15537652, ECO:0000269|PubMed:8206991}. Nucleus {ECO:0000269|PubMed:15537652}. Cell membrane {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:8206991}. Perikaryon {ECO:0000250|UniProtKB:Q62844}. Note=Present and active in lipid rafts (PubMed:12218089). Palmitoylation is crucial for proper trafficking (PubMed:8206991). {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:8206991}. |
| Mouse PG classification | NA |
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