| Gene Information | |
|---|---|
| Gene Name | FYB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 783 |
| Protein Names | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000082074 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O15117 |
| Gene Card | FYB1 |
| Uniprot ID | O15117 |
| Pfam | PF14603; PF07653 |
| In ASD | no |
| Allosteric Prediction | yes (0.157701255) |
| Ortholog in Animals | Alpaca_ FYB1 ( ortholog_one2one ) Dog_ FYB1 ( ortholog_one2one ) GuineaPig_ FYB1 ( ortholog_one2one ) Macaque_ FYB1 ( ortholog_one2one ) Mouse_ Fyb ( ortholog_one2one ) Pig_ FYB1 ( ortholog_one2one ) Rat_ Fyb1 ( ortholog_one2one ) Rabbit_ FYB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRAM1, FYB2 |
| Tissue | whole.blood |
| Tissue Specificity | Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1RI9 (NMR - ) 2GTJ (NMR - ) 2GTO (NMR - ) |
| DBSNP | rs1642515 rs3749741 rs379707 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000250|UniProtKB:O35601}. Note=Colocalizes with TMEM47 at cell-cell contacts in podocytes. {ECO:0000250|UniProtKB:O35601}. |
| Mouse PG classification | NA |
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