| Gene Information | |
|---|---|
| Gene Name | CNTNAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1384 |
| Protein Names | Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000108797 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P78357 |
| Gene Card | CNTNAP1 |
| Uniprot ID | P78357 |
| Pfam | PF00754; PF02210 |
| In ASD | no |
| Allosteric Prediction | no (-0.153258245) |
| Ortholog in Animals | Alpaca_ CNTNAP1 ( ortholog_one2one ) Dog_ CNTNAP1 ( ortholog_one2one ) GuineaPig_ CNTNAP1 ( ortholog_one2one ) Macaque_ CNTNAP1 ( ortholog_one2one ) Mouse_ Cntnap1 ( ortholog_one2one ) Pig_ CNTNAP1 ( ortholog_one2one ) Rat_ Cntnap1 ( ortholog_one2one ) Rabbit_ CNTNAP1 ( ortholog_one2one ) |
| Ohnologs | CNTNAP4, CNTNAP5, CNTNAP2 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1567969825 rs768554986 rs779027563 rs35437096 rs761805324 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:O54991}. |
| Mouse PG classification | LPG |
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