| Gene Information | |
|---|---|
| Gene Name | FXYD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 92 |
| Protein Names | Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 101 ( ENSG00000266964 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00168 |
| Gene Card | FXYD1 |
| Uniprot ID | O00168 |
| Pfam | PF02038 |
| In ASD | no |
| Allosteric Prediction | no (-1.04394035) |
| Ortholog in Animals | Alpaca_ FXYD1 ( ortholog_one2one ) Dog_ FXYD1 ( ortholog_one2one ) GuineaPig_ FXYD1 ( ortholog_one2one ) Macaque_ FXYD1 ( ortholog_one2one ) Mouse_ Fxyd1 ( ortholog_one2one ) Rat_ Fxyd1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FXYD7, FXYD2, FXYD5, FXYD3, FXYD4, FXYD6 |
| Tissue | heart, skeletal.muscle |
| Tissue Specificity | Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. {ECO:0000269|PubMed:9169143}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JO1 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |