| Gene Information | |
|---|---|
| Gene Name | FXR |
| Organism | Homo sapiens (Human) |
| Gene Length | 486 |
| Protein Names | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96RI1 |
| Gene Card | NR1H4 |
| Uniprot ID | Q96RI1 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximately equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximately equal proportions. Expressed in pancreatic beta cells and macrophages. {ECO:0000269|PubMed:19393742, ECO:0000269|PubMed:19864602, ECO:0000269|PubMed:20447400, ECO:0000269|PubMed:23928191}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OSH (X-ray 1.80A ) 3BEJ (X-ray 1.90A ) 3DCT (X-ray 2.50A ) 3DCU (X-ray 2.95A ) 3FLI (X-ray 2.00A ) 3FXV (X-ray 2.26A ) 3GD2 (X-ray 3.20A ) 3HC5 (X-ray 2.60A ) 3HC6 (X-ray 3.20A ) 3L1B (X-ray 1.90A ) 3OKH (X-ray 2.50A ) 3OKI (X-ray 2.00A ) 3OLF (X-ray 1.90A ) 3OMK (X-ray 1.90A ) 3OMM (X-ray 2.10A ) 3OOF (X-ray 2.29A ) 3OOK (X-ray 2.29A ) 3P88 (X-ray 2.95A ) 3P89 (X-ray 2.30A ) 3RUT (X-ray 3.00A ) 3RUU (X-ray 2.50A ) 3RVF (X-ray 3.10A ) 4OIV (X-ray 1.70A ) 4QE6 4QE8 (X-ray 2.62A ) 4WVD (X-ray 2.90A ) 5IAW (X-ray 2.58A ) 5ICK (X-ray 2.47A ) 5Q0I (X-ray 1.70A ) 5Q0J (X-ray 2.00A ) 5Q0K (X-ray 1.80A ) 5Q0L (X-ray 2.50A ) 5Q0M (X-ray 2.20A ) 5Q0N (X-ray 2.40A ) 5Q0O (X-ray 1.90A ) 5Q0P (X-ray 1.80A ) 5Q0Q (X-ray 2.60A ) 5Q0R (X-ray 1.91A ) 5Q0S (X-ray 2.50A ) 5Q0T (X-ray 2.14A ) 5Q0U (X-ray 1.90A ) 5Q0V (X-ray 1.87A ) 5Q0W (X-ray 1.90A ) 5Q0X (X-ray 2.26A ) 5Q0Y (X-ray 2.20A ) 5Q0Z (X-ray 2.26A ) 5Q10 (X-ray 2.20A ) 5Q11 (X-ray 2.20A ) 5Q12 (X-ray 2.00A ) 5Q13 (X-ray 1.90A ) 5Q14 (X-ray 1.85A ) 5Q15 (X-ray 1.90A ) 5Q16 (X-ray 2.00A ) 5Q17 (X-ray 2.10A ) 5Q18 (X-ray 1.90A ) 5Q19 (X-ray 1.98A ) 5Q1A (X-ray 2.00A ) 5Q1B (X-ray 2.30A ) 5Q1C (X-ray 2.30A ) 5Q1D (X-ray 1.89A ) 5Q1E (X-ray 1.85A ) 5Q1F (X-ray 2.30A ) 5Q1G (X-ray 2.00A ) 5Q1H (X-ray 2.20A ) 5Q1I (X-ray 1.95A ) 5WZX (X-ray 2.95A ) 5Y1J (X-ray 2.00A ) 5Y44 (X-ray 2.35A ) 5Y49 (X-ray 2.40A ) 5YXB (X-ray 2.95A ) 5YXD (X-ray 2.98A ) 5YXJ (X-ray 2.62A ) 5YXL (X-ray 2.24A ) 5Z12 (X-ray 2.75A ) 6A5W (X-ray 2.88A ) 6A5X (X-ray 2.60A ) 6A5Y (X-ray 2.10A ) 6A5Z (X-ray 2.95A ) 6A60 (X-ray 3.05A ) 6HL0 (X-ray 1.66A ) 6HL1 (X-ray 1.65A ) 6ITM (X-ray 2.50A ) 7D42 (X-ray 2.70A ) 7TRB (X-ray 2.15A ) 7VUE (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19864602}.; [Isoform 1]: Nucleus {ECO:0000269|PubMed:23928191}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:23928191}.; [Isoform 3]: Nucleus {ECO:0000269|PubMed:23928191}.; [Isoform 4]: Nucleus {ECO:0000269|PubMed:23928191}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |