| Gene Information | |
|---|---|
| Gene Name | AP1S1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 158 |
| Protein Names | AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000106367 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P61966 |
| Gene Card | AP1S1 |
| Uniprot ID | P61966 |
| Pfam | PF01217 |
| In ASD | no |
| Allosteric Prediction | no (-1.000281552) |
| Ortholog in Animals | Alpaca_ AP1S1 ( ortholog_one2one ) Dog_ AP1S1 ( ortholog_one2one ) GuineaPig_ AP1S1 ( ortholog_one2one ) Macaque_ AP1S1 ( ortholog_one2one ) Mouse_ Ap1s1 ( ortholog_one2one ) Pig_ AP1S1 ( ortholog_one2one ) Rat_ Ap1s1 ( ortholog_one2one ) |
| Ohnologs | AP1S2 |
| Paralogs | AP4S1, AP3S1, AP2S1, AP3S2, AP1S2, AP1S3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9733768}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001759(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4P6Z (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus {ECO:0000269|PubMed:9733768}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9733768}; Peripheral membrane protein {ECO:0000269|PubMed:9733768}; Cytoplasmic side {ECO:0000269|PubMed:9733768}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:9733768}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. |
| Mouse PG classification | NA |
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