| Gene Information | |
|---|---|
| Gene Name | CDH5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 784 |
| Protein Names | Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) |
| Target Name | cadherin-5 |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000179776 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P33151 |
| Gene Card | CDH5 |
| Uniprot ID | P33151 |
| Pfam | PF01049; PF00028 |
| In ASD | no |
| Allosteric Prediction | yes (0.946621932) |
| Ortholog in Animals | Alpaca_ CDH5 ( ortholog_one2one ) Dog_ CDH5 ( ortholog_one2one ) GuineaPig_ CDH5 ( ortholog_one2one ) Macaque_ CDH5 ( ortholog_one2one ) Mouse_ Cdh5 ( ortholog_one2one ) Pig_ CDH5 ( ortholog_one2one ) Rat_ Cdh5 ( ortholog_one2one ) Rabbit_ CDH5 ( ortholog_one2one ) |
| Ohnologs | CDH19, CDH7, CDH20, CDH22, CDH2, CDH4, CDH10, CDH9, CDH6, CDH15, CDH24, CDH18, CDH12 |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDH1, CDHR2, CDH22, CDH2 |
| Tissue | NA |
| Tissue Specificity | Endothelial tissues and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16956504 rs1049970 |
| Subcellular location [CC] | Cell junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21183689}. Cell membrane {ECO:0000269|PubMed:15980433, ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000269|PubMed:20332120}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |