Gene Information
Gene NameCD14
OrganismHomo sapiens (Human)
Gene Length375
Protein NamesMonocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]
Target Namemonocyte differentiation antigen cd14
Target TypeClinical trial target
Gene Age382 ( ENSG00000170458 )
Evolutionary StageMammalia
AlphaFoldDBP08571
Gene CardCD14
Uniprot IDP08571
PfamNA
In ASDno
Allosteric Predictionyes (0.816193241)
Ortholog in AnimalsAlpaca_ CD14 ( ortholog_one2one )
Dog_ CD14 ( ortholog_one2one )
GuineaPig_ CD14 ( ortholog_one2one )
Macaque_ CD14 ( ortholog_one2one )
Mouse_ Cd14 ( ortholog_one2one )
Pig_ CD14 ( ortholog_one2one )
Rat_ Cd14 ( ortholog_one2one )
Rabbit_ CD14 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes;
also expressed by most tissue macrophages. {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:25497142}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4GLP  (X-ray  4.00A  ) 
DBSNP rs2228049  rs11556179 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}. Secreted {ECO:0000269|PubMed:25497142, ECO:0000269|PubMed:2779588}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:2779588, ECO:0000269|PubMed:3385210}.
Mouse PG classificationNA
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