| Gene Information | |
|---|---|
| Gene Name | FUS |
| Organism | Homo sapiens (Human) |
| Gene Length | 526 |
| Protein Names | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000089280 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35637 |
| Gene Card | FUS |
| Uniprot ID | P35637 |
| Pfam | PF00076; PF00641 |
| In ASD | yes |
| Allosteric Prediction | yes (0.442135255) |
| Ortholog in Animals | Alpaca_ FUS ( ortholog_one2one ) Dog_ FUS ( ortholog_one2one ) GuineaPig_ FUS ( ortholog_one2one ) Macaque_ TRIM72 ( ortholog_one2one ) Mouse_ Fus ( ortholog_one2one ) Pig_ FUS ( ortholog_one2one ) Rat_ AABR07037203.1 ( ortholog_one2many ) Rat_ Fus ( ortholog_one2many ) Rabbit_ FUS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EWSR1, TAF15 |
| Tissue | substantia.nigra |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.129424(Rat);0.063433(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LA6 (NMR - ) 2LCW (NMR - ) 4FDD (X-ray 2.30A ) 4FQ3 (X-ray 3.00A ) 5W3N (NMR - ) 5XRR (X-ray 1.50A ) 5XSG (EM 0.73A ) 5YVG (X-ray 4.05A ) 5YVH (X-ray 3.15A ) 5YVI (X-ray 2.90A ) 6BWZ (X-ray 1.10A ) 6BXV (X-ray 1.10A ) 6BZP (EM 1.10A ) 6G99 (NMR - ) 6GBM (NMR - ) 6KJ1 (EM 0.65A ) 6KJ2 (EM 0.67A ) 6KJ3 (EM 0.60A ) 6KJ4 (EM 0.65A ) 6SNJ (NMR - ) 6XFM (EM 2.62A ) 7CYL (X-ray 2.70A ) 7VQQ (EM 2.90A ) |
| DBSNP | rs148758737 rs267606832 rs1567472455 rs748374535 rs777819849 rs1165095258 rs752076094 rs186547381 rs267606831 rs1555509609 rs369757630 rs121909667 rs121909669 rs121909668 rs121909668 rs121909671 rs1555509693 rs886041389 rs544088874 rs886041390 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19251627, ECO:0000269|PubMed:19251628, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:25453086, ECO:0000269|PubMed:30354839}. Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. {ECO:0000269|PubMed:25453086}. |
| Mouse PG classification | LPG |
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