| Gene Information | |
|---|---|
| Gene Name | FURIN |
| Organism | Homo sapiens (Human) |
| Gene Length | 794 |
| Protein Names | Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) |
| Target Name | furin |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000140564 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P09958 |
| Gene Card | FURIN |
| Uniprot ID | P09958 |
| Pfam | PF01483; PF00082; PF16470 |
| In ASD | yes |
| Allosteric Prediction | yes (0.783350565) |
| Ortholog in Animals | Alpaca_ FURIN ( ortholog_one2one ) Dog_ FURIN ( ortholog_one2one ) GuineaPig_ FURIN ( ortholog_one2one ) Macaque_ FURIN ( ortholog_one2one ) Mouse_ Furin ( ortholog_one2one ) Pig_ FURIN ( ortholog_one2one ) Rat_ Furin ( ortholog_one2one ) Rabbit_ FURIN ( ortholog_one2one ) |
| Ohnologs | PCSK4, PCSK1 |
| Paralogs | PCSK1, TPP2, PCSK6, MBTPS1, PCSK7, PCSK5, PCSK9, PCSK4, PCSK2 |
| Tissue | NA |
| Tissue Specificity | Seems to be expressed ubiquitously. {ECO:0000269|PubMed:1713771}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4OMC (X-ray 2.30A ) 4OMD (X-ray 2.70A ) 4RYD (X-ray 2.15A ) 4Z2A (X-ray 1.89A ) 5JMO (X-ray 2.00A ) 5JXG (X-ray 1.80A ) 5JXH (X-ray 2.00A ) 5JXI (X-ray 2.00A ) 5JXJ (X-ray 2.00A ) 5MIM (X-ray 1.90A ) 6A8Y (NMR - ) 6EQV (X-ray 1.90A ) 6EQW (X-ray 1.99A ) 6EQX (X-ray 1.99A ) 6HLB (X-ray 2.00A ) 6HLD (X-ray 2.10A ) 6HLE (X-ray 1.99A ) 6HZA (X-ray 1.90A ) 6HZB (X-ray 1.90A ) 6HZC (X-ray 1.90A ) 6HZD (X-ray 1.90A ) 6YD2 (X-ray 1.80A ) 6YD3 (X-ray 2.00A ) 6YD4 (X-ray 1.70A ) 6YD7 (X-ray 1.80A ) 7LCU (X-ray 1.24A ) 7O1U (X-ray 1.70A ) 7O1W (X-ray 1.80A ) 7O1Y (X-ray 1.70A ) 7O20 (X-ray 1.80A ) 7O22 (X-ray 1.80A ) 7QXY (X-ray 1.48A ) 7QXZ (X-ray 1.80A ) 7QY0 (X-ray 1.54A ) 7QY1 (X-ray 1.45A ) 7QY2 (X-ray 1.55A ) |
| DBSNP | rs16944971 |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:8846780, ECO:0000269|PubMed:9130696, ECO:0000269|PubMed:9412467}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:9130696, ECO:0000269|PubMed:9412467}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000305|PubMed:11799113}. Endosome membrane {ECO:0000269|PubMed:9412467}; Single-pass type I membrane protein {ECO:0000305}. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113). {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:9412467}. |
| Mouse PG classification | NA |
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