| Gene Information | |
|---|---|
| Gene Name | FST |
| Organism | Homo sapiens (Human) |
| Gene Length | 344 |
| Protein Names | Follistatin (FS) (Activin-binding protein) |
| Target Name | follistatin |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000134363 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P19883 |
| Gene Card | FST |
| Uniprot ID | P19883 |
| Pfam | PF09289; PF07648 |
| In ASD | no |
| Allosteric Prediction | yes (0.014834655) |
| Ortholog in Animals | Alpaca_ FST ( ortholog_one2one ) Dog_ FST ( ortholog_one2one ) GuineaPig_ FST ( ortholog_one2one ) Macaque_ FST ( ortholog_one2one ) Mouse_ Fst ( ortholog_one2one ) Pig_ FST ( ortholog_one2one ) Rat_ Fst ( ortholog_one2one ) Rabbit_ FST ( ortholog_one2one ) |
| Ohnologs | FSTL3 |
| Paralogs | FSTL3, SPINK6, FSTL1, FSTL5, SPINK5, FSTL4 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115). {ECO:0000269|PubMed:15472207, ECO:0000269|PubMed:31215115}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);0.002419(Rat);0.085714(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2B0U (X-ray 2.80A ) 2P6A (X-ray 3.40A ) 3HH2 (X-ray 2.15A ) 5JHW (X-ray 2.35A ) |
| DBSNP | rs11745088 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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