| Gene Information | |
|---|---|
| Gene Name | FSD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 749 |
| Protein Names | Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000186628 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | A1L4K1 |
| Gene Card | FSD2 |
| Uniprot ID | A1L4K1 |
| Pfam | PF00041; PF00622 |
| In ASD | no |
| Allosteric Prediction | no (-1.413842245) |
| Ortholog in Animals | Alpaca_ FSD2 ( ortholog_one2one ) Dog_ FSD2 ( ortholog_one2one ) GuineaPig_ FSD2 ( ortholog_one2one ) Macaque_ FSD2 ( ortholog_one2one ) Mouse_ Fsd2 ( ortholog_one2one ) Pig_ FSD2 ( ortholog_one2one ) Rat_ Fsd2 ( ortholog_one2one ) Rabbit_ FSD2 ( ortholog_one2one ) |
| Ohnologs | MID2, FSD1, FSD1L, TRIM36, TRIM46 |
| Paralogs | CMYA5, FSD1L, FSD1 |
| Tissue | heart, skeletal.muscle, artery |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4779061 rs1108134 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:H0UZ81}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:H0UZ81}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:H0UZ81}. Note=In skeletal muscles and striated muscles flanks Z-disks. Partially colocalizes with RYR2 in the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:H0UZ81}. |
| Mouse PG classification | NA |
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