| Gene Information | |
|---|---|
| Gene Name | FRPHE |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q6FHJ7 |
| Gene Card | SFRP4 |
| Uniprot ID | Q6FHJ7 |
| Pfam | PF01392; PF01759 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269|PubMed:10728394, ECO:0000269|PubMed:19480240}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1802073 rs1802074 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells. |
| Mouse PG classification | NA |
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