| Gene Information | |
|---|---|
| Gene Name | DIO2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 273 |
| Protein Names | Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000211448 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | DIO2 |
| Uniprot ID | Q92813 |
| Pfam | PF00837 |
| In ASD | no |
| Allosteric Prediction | no (-0.07236912) |
| Ortholog in Animals | Alpaca_ DIO2 ( ortholog_one2one ) Dog_ DIO2 ( ortholog_one2one ) GuineaPig_ Dio2 ( ortholog_one2one ) Mouse_ Dio2 ( ortholog_one2one ) Pig_ DIO2 ( ortholog_one2one ) Rat_ Dio2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DIO3, DIO1 |
| Tissue | thyroid |
| Tissue Specificity | Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050). Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050). {ECO:0000269|PubMed:11165050, ECO:0000269|PubMed:8755651}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2839859 rs225014 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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