| Gene Information | |
|---|---|
| Gene Name | FRK |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) |
| Target Name | tyrosine-protein kinase frk |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000111816 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P42685 |
| Gene Card | FRK |
| Uniprot ID | P42685 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (1.149535928) |
| Ortholog in Animals | Alpaca_ FRK ( ortholog_one2one ) Dog_ FRK ( ortholog_one2one ) GuineaPig_ FRK ( ortholog_one2one ) Macaque_ FRK ( ortholog_one2one ) Mouse_ Frk ( ortholog_one2one ) Pig_ FRK ( ortholog_one2one ) Rat_ Frk ( ortholog_one2one ) Rabbit_ FRK ( ortholog_one2one ) |
| Ohnologs | HCK, YES1, SRC, FGR, LCK |
| Paralogs | FGR, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | kidney, small.intestine |
| Tissue Specificity | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. {ECO:0000269|PubMed:7696183}. |
| Pharmacological Animal Models | 0.019824(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs34704018 rs3756772 rs34064900 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:7696183}. Nucleus {ECO:0000269|PubMed:7696183}. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery. |
| Mouse PG classification | NA |
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