Gene Information
Gene NameFRAP
OrganismHomo sapiens (Human)
Gene Length2549
Protein NamesSerine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP42345
Gene CardMTOR
Uniprot IDP42345
PfamPF11865; PF02259; PF02260; PF08771; PF00454
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in numerous tissues, with highest levels in testis. {ECO:0000269|PubMed:12408816, ECO:0000269|PubMed:7809080}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.071024(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AUE  (X-ray  2.33A  )  1FAP  (X-ray  2.70A  )  1NSG  (X-ray  2.20A  )  2FAP  (X-ray  2.20A  )  2GAQ  (NMR  -  )  2NPU  (NMR  -  )  2RSE  (NMR  -  )  3FAP  (X-ray  1.85A  )  3JBZ  (EM  28.00A  )  4DRH  (X-ray  2.30A  )  4DRI  (X-ray  1.45A  )  4DRJ  (X-ray  1.80A  )  4FAP  (X-ray  2.80A  )  4JSN  (X-ray  3.20A  )  4JSP  (X-ray  3.30A  )  4JSV  (X-ray  3.50A  )  4JSX  (X-ray  3.50A  )  4JT5  (X-ray  3.45A  )  4JT6  (X-ray  3.60A  )  5FLC  (EM  5.90A  )  5GPG  (X-ray  1.67A  )  5H64  (EM  4.40A  )  5WBH  (X-ray  1.75A  )  5WBU  (X-ray  3.42A  )  5WBY  (X-ray  3.10A  )  5ZCS  (EM  4.90A  )  6BCU  (EM  3.43A  )  6BCX  (EM  3.00A  )  6M4U  (X-ray  2.20A  )  6M4W  (X-ray  3.11A  )  6SB0  (EM  5.50A  )  6SB2  (EM  6.20A  )  6ZWM  (EM  3.20A  )  6ZWO  (EM  3.00A  )  7EPD  (EM  3.90A  )  7OWG  (EM  4.70A  )  7PE7  (EM  3.41A  )  7PE8  (EM  3.20A  )  7PE9  (EM  3.70A  )  7PEA  (EM  4.07A  )  7PEB  (EM  3.67A  )  7PEC  (EM  4.24A  ) 
DBSNP rs913197212  rs56164650  rs28730685  rs55975118  rs975577894  rs1085307114  rs1057519779  rs1057519914  rs869312671  rs587777895  rs863225264  rs369088781  rs869312666  rs587777893  rs587777894  rs587777894  rs878855328  rs1085307113  rs1085307113  rs968817513 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:14578359};
Peripheral membrane protein {ECO:0000269|PubMed:14578359};
Cytoplasmic side {ECO:0000269|PubMed:14578359}. Golgi apparatus membrane {ECO:0000269|PubMed:14578359};
Peripheral membrane protein {ECO:0000269|PubMed:14578359};
Cytoplasmic side {ECO:0000269|PubMed:14578359}. Mitochondrion outer membrane {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359};
Peripheral membrane protein {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359};
Cytoplasmic side {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}. Lysosome {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:29750193}. Cytoplasm {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:18497260}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9JLN9}. Microsome membrane {ECO:0000269|PubMed:9434772}. Lysosome membrane {ECO:0000269|PubMed:30956113}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:27623384}. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:29750193, ECO:0000269|PubMed:30956113}.
Mouse PG classificationNA
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