| Gene Information | |
|---|---|
| Gene Name | ACKR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 384 |
| Protein Names | Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000144648 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00590 |
| Gene Card | ACKR2 |
| Uniprot ID | O00590 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | no (-0.624503103) |
| Ortholog in Animals | Alpaca_ ACKR2 ( ortholog_one2one ) GuineaPig_ ACKR2 ( ortholog_one2one ) Macaque_ ACKR2 ( ortholog_one2one ) Mouse_ Ackr2 ( ortholog_one2one ) Pig_ ACKR2 ( ortholog_one2one ) Rat_ Ackr2 ( ortholog_one2one ) Rabbit_ ACKR2 ( ortholog_one2one ) |
| Ohnologs | CCR10, CXCR3, ACKR3, CXCR1, CXCR2 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, CCR4, CX3CR1, CCR2, CCR5, CCR3 |
| Tissue | placenta |
| Tissue Specificity | Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. {ECO:0000269|PubMed:11238036, ECO:0000269|PubMed:22651933, ECO:0000269|PubMed:23479571}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2228467 rs2228469 rs6779520 rs2228468 |
| Subcellular location [CC] | Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| Mouse PG classification | NA |
| click here to return to the previous page | |