| Gene Information | |
|---|---|
| Gene Name | FPR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) |
| Target Name | fmet-leu-phe receptor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171051 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21462 |
| Gene Card | FPR1 |
| Uniprot ID | P21462 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.692968838) |
| Ortholog in Animals | Alpaca_ FPR1 ( ortholog_one2one ) Macaque_ FPR1 ( ortholog_one2one ) Mouse_ Fpr1 ( ortholog_one2one ) Rat_ Fpr1 ( ortholog_one2one ) Rabbit_ FPR1 ( ortholog_one2one ) |
| Ohnologs | CMKLR1 |
| Paralogs | FPR2, FPR3, GPR32, C5AR1, C5AR2, C3AR1, CMKLR1, GPR33 |
| Tissue | whole.blood |
| Tissue Specificity | Neutrophils. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7EUO (EM 2.90A ) 7T6T (EM 3.20A ) 7WVU (EM 3.30A ) |
| DBSNP | rs5030878 rs2070745 rs5030880 rs1042229 rs867228 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2176894, ECO:0000269|PubMed:25109685, ECO:0000305|PubMed:10514456}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG. {ECO:0000269|PubMed:15210802, ECO:0000269|PubMed:25109685}. |
| Mouse PG classification | NA |
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