| Gene Information | |
|---|---|
| Gene Name | PRMT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 433 |
| Protein Names | Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000160310 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55345 |
| Gene Card | PRMT2 |
| Uniprot ID | P55345 |
| Pfam | PF05175; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.424657736) |
| Ortholog in Animals | Alpaca_ PRMT2 ( ortholog_one2one ) Dog_ PRMT2 ( ortholog_one2one ) GuineaPig_ PRMT2 ( ortholog_one2one ) Macaque_ PRMT2 ( ortholog_one2one ) Mouse_ Prmt2 ( ortholog_one2one ) Pig_ PRMT2 ( ortholog_one2one ) Rat_ Prmt2 ( ortholog_one2one ) Rabbit_ PRMT2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRMT7, PRMT9, PRMT1, CARM1, PRMT6, PRMT3, PRMT8 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. {ECO:0000269|PubMed:17587566}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1X2P (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2L2]: Cytoplasm {ECO:0000269|PubMed:21820040}. Nucleus {ECO:0000269|PubMed:21820040}. Note=Predominantly cytoplasmic. |
| Mouse PG classification | NA |
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