| Gene Information | |
|---|---|
| Gene Name | NAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000171428 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q99624 |
| Gene Card | SLC38A3 |
| Uniprot ID | Q99624 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | yes (0.96524351) |
| Ortholog in Animals | Alpaca_ NAT1 ( ortholog_one2one ) Macaque_ NAT1 ( ortholog_one2one ) Mouse_ Nat1 ( ortholog_many2many ) Mouse_ Nat3 ( ortholog_many2many ) Mouse_ Nat2 ( ortholog_many2many ) Rat_ Nat1 ( ortholog_many2many ) Rat_ Nat3 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | NAT2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9DCP2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9DCP2}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9}. |
| Mouse PG classification | NA |
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