| Gene Information | |
|---|---|
| Gene Name | FOXM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000111206 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q08050 |
| Gene Card | FOXM1 |
| Uniprot ID | Q08050 |
| Pfam | PF00250 |
| In ASD | no |
| Allosteric Prediction | yes (0.422596884) |
| Ortholog in Animals | Alpaca_ FOXM1 ( ortholog_one2one ) Dog_ FOXM1 ( ortholog_one2one ) GuineaPig_ FOXM1 ( ortholog_one2one ) Macaque_ FOXM1 ( ortholog_one2one ) Mouse_ Foxm1 ( ortholog_one2one ) Pig_ FOXM1 ( ortholog_one2one ) Rat_ Foxm1 ( ortholog_one2one ) Rabbit_ FOXM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FOXH1, FOXL3, FOXK2, FOXQ1, FOXP3, FOXB2, FOXR1, FOXI2, FOXD2, FOXA2, FOXJ2, FOXD4L1, FOXD4L3, FOXD4L6, FOXD4, FOXD4L5, FOXD4L4, FOXS1, FOXC1, FOXL1, FOXP1, FOXC2, FOXF1, FOXB1, FOXO4, FOXK1, FOXA1, FOXL2, FOXE1, FOXR2, FOXE3, FOXO3B, FOXO3, FOXJ3, FOXD1, FOXD3, FOXO1, FOXI3, FOXJ1, FOXO6, FOXA3, FOXN1 |
| Tissue | brain, testis |
| Tissue Specificity | Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3G73 (X-ray 2.21A ) 7FJ2 (X-ray 3.10A ) |
| DBSNP | rs28990715 rs28919868 rs3742076 rs28919869 rs28919870 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |