| Gene Information | |
|---|---|
| Gene Name | FOXL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 376 |
| Protein Names | Forkhead box protein L2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000183770 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P58012 |
| Gene Card | FOXL2 |
| Uniprot ID | P58012 |
| Pfam | PF00250 |
| In ASD | no |
| Allosteric Prediction | no (-0.503755668) |
| Ortholog in Animals | Macaque_ FOXL2 ( ortholog_one2one ) Mouse_ Foxl2 ( ortholog_one2one ) Rat_ Foxl2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FOXH1, FOXL3, FOXK2, FOXM1, FOXQ1, FOXP3, FOXB2, FOXR1, FOXI2, FOXD2, FOXA2, FOXJ2, FOXD4L1, FOXD4L3, FOXD4L6, FOXD4, FOXD4L5, FOXD4L4, FOXS1, FOXC1, FOXL1, FOXP1, FOXC2, FOXF1, FOXB1, FOXO4, FOXK1, FOXA1, FOXE1, FOXR2, FOXE3, FOXO3B, FOXO3, FOXJ3, FOXD1, FOXD3, FOXO1, FOXI3, FOXJ1, FOXO6, FOXA3, FOXN1 |
| Tissue | ovary |
| Tissue Specificity | In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7VOU (X-ray 3.10A ) 7VOV (X-ray 3.15A ) |
| DBSNP | rs1315073489 rs1559922621 rs387906920 rs28937884 rs1057516149 rs1057516151 rs1057516153 rs1057516156 rs1057519865 rs7432551 rs121908359 rs1057516162 rs1057516168 rs797044527 rs28937885 rs201840174 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19744555}. |
| Mouse PG classification | HPG |
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