| Gene Information | |
|---|---|
| Gene Name | FOXK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 733 |
| Protein Names | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000164916 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P85037 |
| Gene Card | FOXK1 |
| Uniprot ID | P85037 |
| Pfam | PF00498; PF00250 |
| In ASD | no |
| Allosteric Prediction | no (-0.588274608) |
| Ortholog in Animals | Alpaca_ FOXK1 ( ortholog_one2one ) Dog_ FOXK1 ( ortholog_one2one ) GuineaPig_ FOXK1 ( ortholog_one2one ) Macaque_ FOXK1 ( ortholog_one2one ) Mouse_ Foxk1 ( ortholog_one2one ) Pig_ FOXK1 ( ortholog_one2one ) Rat_ Foxk1 ( ortholog_one2one ) Rabbit_ FOXK1 ( ortholog_one2one ) |
| Ohnologs | FOXK2 |
| Paralogs | FOXH1, FOXL3, FOXK2, FOXM1, FOXQ1, FOXP3, FOXB2, FOXR1, FOXI2, FOXD2, FOXA2, FOXJ2, FOXD4L1, FOXD4L3, FOXD4L6, FOXD4, FOXD4L5, FOXD4L4, FOXS1, FOXC1, FOXL1, FOXP1, FOXC2, FOXF1, FOXB1, FOXO4, FOXA1, FOXL2, FOXE1, FOXR2, FOXE3, FOXO3B, FOXO3, FOXJ3, FOXD1, FOXD3, FOXO1, FOXI3, FOXJ1, FOXO6, FOXA3, FOXN1 |
| Tissue | NA |
| Tissue Specificity | Expressed both developing and adult tissues (PubMed:15289879). In adults, significant expression is seen in tumors of the brain, colon and lymph node (PubMed:15289879). {ECO:0000269|PubMed:15289879}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}. Cytoplasm {ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}. Note=Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:25852164}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |