| Gene Information | |
|---|---|
| Gene Name | NOX4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 578 |
| Protein Names | NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase) |
| Target Name | nadph oxidase 4 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000086991 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPH5 |
| Gene Card | NOX4 |
| Uniprot ID | Q9NPH5 |
| Pfam | PF08022; PF01794; PF08030 |
| In ASD | no |
| Allosteric Prediction | yes (0.421263203) |
| Ortholog in Animals | Alpaca_ NOX4 ( ortholog_one2one ) Dog_ NOX4 ( ortholog_one2one ) GuineaPig_ NOX4 ( ortholog_one2one ) Macaque_ NOX4 ( ortholog_one2one ) Mouse_ Nox4 ( ortholog_one2one ) Pig_ NOX4 ( ortholog_one2one ) Rat_ Nox4 ( ortholog_one2one ) Rabbit_ NOX4 ( ortholog_one2one ) |
| Ohnologs | NOX1, NOX3 |
| Paralogs | NOX3, NOX1, DUOX1, NOX5, DUOX2, CYBB |
| Tissue | kidney |
| Tissue Specificity | Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. {ECO:0000269|PubMed:11032835, ECO:0000269|PubMed:11376945, ECO:0000269|PubMed:15210697, ECO:0000269|PubMed:16324151}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs317139 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:26742780}; Multi-pass membrane protein. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000305}. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.; [Isoform 4]: Nucleus {ECO:0000269|PubMed:23393389}. Nucleus, nucleolus {ECO:0000269|PubMed:23393389}. |
| Mouse PG classification | NA |
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