| Gene Information | |
|---|---|
| Gene Name | TAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 686 |
| Protein Names | Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000204267 ) 3 ( ENSG00000206235 ) 3 ( ENSG00000206299 ) 3 ( ENSG00000223481 ) 3 ( ENSG00000225967 ) 3 ( ENSG00000228582 ) 3 ( ENSG00000232326 ) 3 ( ENSG00000237599 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q03519 |
| Gene Card | TAP2 |
| Uniprot ID | Q03519 |
| Pfam | PF00664; PF00005 |
| In ASD | no |
| Allosteric Prediction | no (-0.233630888) |
| Ortholog in Animals | Alpaca_ TAP2 ( ortholog_one2one ) Dog_ TAP2 ( ortholog_one2one ) GuineaPig_ TAP2 ( ortholog_one2one ) Macaque_ TAP2 ( ortholog_one2one ) Mouse_ Tap2 ( ortholog_one2one ) Pig_ TAP2 ( ortholog_one2one ) Rat_ Tap2 ( ortholog_one2one ) Rabbit_ TAP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ABCB6, TAP1, ABCB11, ABCB4, ABCB9, ABCB8, ABCB7, ABCB1, ABCB10, ABCB5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5U1D (EM 3.97A ) |
| DBSNP | rs17220192 rs111303994 rs1800454 rs150253319 rs2228396 rs2228391 rs4148876 rs241447 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:1589036, ECO:0000269|PubMed:22638925}; Multi-pass membrane protein {ECO:0000255}. Note=The transmembrane segments seem to form a pore in the membrane. |
| Mouse PG classification | NA |
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