| Gene Information | |
|---|---|
| Gene Name | FOXA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000170608 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P55318 |
| Gene Card | FOXA3 |
| Uniprot ID | P55318 |
| Pfam | PF00250; PF08430 |
| In ASD | no |
| Allosteric Prediction | yes (0.017119691) |
| Ortholog in Animals | Alpaca_ FOXA3 ( ortholog_one2one ) Dog_ FOXA3 ( ortholog_one2one ) GuineaPig_ FOXA3 ( ortholog_one2one ) Macaque_ FOXA3 ( ortholog_one2one ) Mouse_ Foxa3 ( ortholog_one2one ) Pig_ FOXA3 ( ortholog_one2one ) Rat_ Foxa3 ( ortholog_one2one ) Rabbit_ FOXA3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FOXH1, FOXL3, FOXK2, FOXM1, FOXQ1, FOXP3, FOXB2, FOXR1, FOXI2, FOXD2, FOXA2, FOXJ2, FOXD4L1, FOXD4L3, FOXD4L6, FOXD4, FOXD4L5, FOXD4L4, FOXS1, FOXC1, FOXL1, FOXP1, FOXC2, FOXF1, FOXB1, FOXO4, FOXK1, FOXA1, FOXL2, FOXE1, FOXR2, FOXE3, FOXO3B, FOXO3, FOXJ3, FOXD1, FOXD3, FOXO1, FOXI3, FOXJ1, FOXO6, FOXN1 |
| Tissue | colon, liver, pancreas, rectum, small.intestine, stomach, transverse.colon |
| Tissue Specificity | Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined. {ECO:0000269|PubMed:8499623}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1VTN (X-ray 2.50A ) |
| DBSNP | rs758330593 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19706729}. |
| Mouse PG classification | NA |
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