| Gene Information | |
|---|---|
| Gene Name | GDNF |
| Organism | Homo sapiens (Human) |
| Gene Length | 211 |
| Protein Names | Glial cell line-derived neurotrophic factor (hGDNF) (Astrocyte-derived trophic factor) (ATF) |
| Target Name | glial cell line-derived neurotrophic factor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000168621 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P39905 |
| Gene Card | GDNF |
| Uniprot ID | P39905 |
| Pfam | PF00019 |
| In ASD | no |
| Allosteric Prediction | yes (0.432347989) |
| Ortholog in Animals | Alpaca_ GDNF ( ortholog_one2one ) Dog_ GDNF ( ortholog_one2one ) GuineaPig_ GDNF ( ortholog_one2one ) Macaque_ GDNF ( ortholog_one2one ) Mouse_ Gdnf ( ortholog_one2one ) Pig_ GDNF ( ortholog_one2one ) Rat_ Gdnf ( ortholog_one2one ) Rabbit_ GDNF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRTN, ARTN, PSPN |
| Tissue | NA |
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. {ECO:0000269|PubMed:22081608, ECO:0000269|PubMed:7867768}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.019071(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2V5E (X-ray 2.35A ) 3FUB (X-ray 2.35A ) 4UX8 (EM 24.00A ) 6Q2N (EM 4.40A ) |
| DBSNP | rs777451569 rs36119840 rs76466003 rs104893891 rs121918536 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:9811930}. |
| Mouse PG classification | NA |
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