| Gene Information | |
|---|---|
| Gene Name | FOS |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) |
| Target Name | activator protein 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000170345 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P01100 |
| Gene Card | FOS |
| Uniprot ID | P01100 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | yes (0.449130433) |
| Ortholog in Animals | Alpaca_ FOS ( ortholog_one2one ) Dog_ FOS ( ortholog_one2one ) GuineaPig_ FOS ( ortholog_one2one ) Macaque_ FOS ( ortholog_one2one ) Mouse_ Fos ( ortholog_one2one ) Pig_ FOS ( ortholog_one2one ) Rat_ Fos ( ortholog_one2one ) Rabbit_ FOS ( ortholog_one2one ) |
| Ohnologs | FOSB, FOSL2, FOSL1 |
| Paralogs | BATF, FOSL1, FOSL2, JDP2, ATF3, BATF3, BATF2, FOSB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.154098(Mouse);0.419739(Rat);0.128987(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A02 (X-ray 2.70A ) 1FOS (X-ray 3.05A ) 1S9K (X-ray 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30. |
| Mouse PG classification | NA |
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