| Gene Information | |
|---|---|
| Gene Name | IL18RAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 599 |
| Protein Names | Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115607 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95256 |
| Gene Card | IL18RAP |
| Uniprot ID | O95256 |
| Pfam | PF18452; PF01582 |
| In ASD | yes |
| Allosteric Prediction | yes (0.15644592) |
| Ortholog in Animals | Alpaca_ IL18RAP ( ortholog_one2one ) Dog_ IL18RAP ( ortholog_one2one ) GuineaPig_ IL18RAP ( ortholog_one2one ) Macaque_ IL18RAP ( ortholog_one2one ) Mouse_ Il18rap ( ortholog_one2one ) Pig_ IL18RAP ( ortholog_one2one ) Rat_ Il18rap ( ortholog_one2one ) Rabbit_ IL18RAP ( ortholog_one2one ) |
| Ohnologs | IL1RAPL2, IL1RAP |
| Paralogs | IL1R1, LAG3, IL18R1, IL1R2, IL1RL1, IL1RL2, IL1RAP, SIGIRR, IL1RAPL2, IL1RAPL1 |
| Tissue | bone.marrow, spleen, whole.blood |
| Tissue Specificity | Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10925275, PubMed:11046021, PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:10925275, ECO:0000269|PubMed:11046021, ECO:0000269|PubMed:17897836, ECO:0000269|PubMed:9792649}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.4(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3WO4 (X-ray 3.10A ) 6KN9 (X-ray 3.30A ) 7FCH (X-ray 1.88A ) |
| DBSNP | rs11465716 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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