| Gene Information | |
|---|---|
| Gene Name | FNDC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 212 |
| Protein Names | Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000160097 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8NAU1 |
| Gene Card | FNDC5 |
| Uniprot ID | Q8NAU1 |
| Pfam | PF16066; PF00041 |
| In ASD | no |
| Allosteric Prediction | no (-0.732883913) |
| Ortholog in Animals | Alpaca_ FNDC5 ( ortholog_one2one ) Dog_ FNDC5 ( ortholog_one2one ) GuineaPig_ FNDC5 ( ortholog_one2one ) Macaque_ FNDC5 ( ortholog_one2one ) Mouse_ Fndc5 ( ortholog_one2one ) Pig_ FNDC5 ( ortholog_one2one ) Rat_ Fndc5 ( ortholog_one2one ) Rabbit_ FNDC5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FNDC4 |
| Tissue | skeletal.muscle, heart, ovary |
| Tissue Specificity | Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen. {ECO:0000269|PubMed:24040023}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4LSD (X-ray 2.28A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22237023}; Single-pass type I membrane protein {ECO:0000269|PubMed:22237023}. Peroxisome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Imported in peroxisomes through the PEX5 receptor pathway. {ECO:0000250}.; [Irisin]: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. {ECO:0000269|PubMed:22237023}. |
| Mouse PG classification | NA |
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