Gene Information
Gene NameFN
OrganismHomo sapiens (Human)
Gene Length2477
Protein NamesFibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP02751
Gene CardFN1
Uniprot IDP02751
PfamPF00039; PF00040; PF00041
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine (PubMed:17614963). {ECO:0000269|PubMed:17614963, ECO:0000269|PubMed:29777959, ECO:0000269|PubMed:3584091}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.658232(Rat);0.167890(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1E88  (NMR  1E8B  (NMR  1FBR  (NMR  1FNA  (X-ray  1.80A  1FNF  (X-ray  2.00A  1FNH  (X-ray  2.80A  1J8K  (NMR  1O9A  (NMR  1OWW  (NMR  1Q38  (NMR  1QGB  (NMR  1QO6  (NMR  1TTF  (NMR  1TTG  (NMR  2CG6  (X-ray  1.55A  2CG7  (X-ray  1.20A  2CK2  (X-ray  2.00A  2CKU  (NMR  2EC3  (NMR  2FN2  (NMR  2FNB  (NMR  2GEE  (X-ray  2.01A  2H41  (NMR  2H45  (NMR  2HA1  (NMR  2MNU  (NMR  2N1K  (NMR  2OCF  (X-ray  2.95A  2RKY  (X-ray  1.80A  2RKZ  (X-ray  2.00A  2RL0  (X-ray  2.00A  3CAL  (X-ray  1.70A  3EJH  (X-ray  2.10A  3GXE  (X-ray  2.60A  3M7P  (X-ray  2.50A  3MQL  (X-ray  3.00A  3R8Q  (X-ray  2.40A  3T1W  (X-ray  2.40A  3ZRZ  (X-ray  1.70A  4GH7  (X-ray  2.60A  4JE4  (X-ray  2.31A  4JEG  (X-ray  2.30A  4LXO  (X-ray  1.42A  4MMX  (X-ray  3.32A  4MMY  (X-ray  3.18A  4MMZ  (X-ray  3.10A  4PZ5  (X-ray  1.96A  5DC0  (X-ray  2.23A  5DC4  (X-ray  1.48A  5DC9  (X-ray  1.56A  5DFT  (X-ray  2.50A  5J6Z  (NMR  5J7C  (X-ray  2.54A  5M0A  (NMR  5N47  (X-ray  3.00A  5N48  (X-ray  1.60A  6HNF  (NMR  6MFA  (X-ray  1.75A  6MSV  (X-ray  2.40A  6NAJ  (X-ray  3.10A  6XAX  (X-ray  2.40A  6XAY  (X-ray  2.48A  7NWL  (EM  3.10A 
DBSNP rs1250259  rs1553669703  rs1553667072  rs1181638652  rs1553659131  rs1553658926  rs1553636502  rs2577301  rs752106647  rs137854488  rs11687611  rs137854486  rs137854487  rs1250209  rs17449032  rs1250209  rs1373375768 
Subcellular location [CC]Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:29100092}.
Mouse PG classificationNA
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