Gene Information | |
---|---|
Gene Name | FN |
Organism | Homo sapiens (Human) |
Gene Length | 2477 |
Protein Names | Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3] |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | P02751 |
Gene Card | FN1 |
Uniprot ID | P02751 |
Pfam | PF00039; PF00040; PF00041 |
In ASD | yes |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine (PubMed:17614963). {ECO:0000269|PubMed:17614963, ECO:0000269|PubMed:29777959, ECO:0000269|PubMed:3584091}. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.658232(Rat);0.167890(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1E88 (NMR - ) 1E8B (NMR - ) 1FBR (NMR - ) 1FNA (X-ray 1.80A ) 1FNF (X-ray 2.00A ) 1FNH (X-ray 2.80A ) 1J8K (NMR - ) 1O9A (NMR - ) 1OWW (NMR - ) 1Q38 (NMR - ) 1QGB (NMR - ) 1QO6 (NMR - ) 1TTF (NMR - ) 1TTG (NMR - ) 2CG6 (X-ray 1.55A ) 2CG7 (X-ray 1.20A ) 2CK2 (X-ray 2.00A ) 2CKU (NMR - ) 2EC3 (NMR - ) 2FN2 (NMR - ) 2FNB (NMR - ) 2GEE (X-ray 2.01A ) 2H41 (NMR - ) 2H45 (NMR - ) 2HA1 (NMR - ) 2MNU (NMR - ) 2N1K (NMR - ) 2OCF (X-ray 2.95A ) 2RKY (X-ray 1.80A ) 2RKZ (X-ray 2.00A ) 2RL0 (X-ray 2.00A ) 3CAL (X-ray 1.70A ) 3EJH (X-ray 2.10A ) 3GXE (X-ray 2.60A ) 3M7P (X-ray 2.50A ) 3MQL (X-ray 3.00A ) 3R8Q (X-ray 2.40A ) 3T1W (X-ray 2.40A ) 3ZRZ (X-ray 1.70A ) 4GH7 (X-ray 2.60A ) 4JE4 (X-ray 2.31A ) 4JEG (X-ray 2.30A ) 4LXO (X-ray 1.42A ) 4MMX (X-ray 3.32A ) 4MMY (X-ray 3.18A ) 4MMZ (X-ray 3.10A ) 4PZ5 (X-ray 1.96A ) 5DC0 (X-ray 2.23A ) 5DC4 (X-ray 1.48A ) 5DC9 (X-ray 1.56A ) 5DFT (X-ray 2.50A ) 5J6Z (NMR - ) 5J7C (X-ray 2.54A ) 5M0A (NMR - ) 5N47 (X-ray 3.00A ) 5N48 (X-ray 1.60A ) 6HNF (NMR - ) 6MFA (X-ray 1.75A ) 6MSV (X-ray 2.40A ) 6NAJ (X-ray 3.10A ) 6XAX (X-ray 2.40A ) 6XAY (X-ray 2.48A ) 7NWL (EM 3.10A ) |
DBSNP | rs1250259 rs1553669703 rs1553667072 rs1181638652 rs1553659131 rs1553658926 rs1553636502 rs2577301 rs752106647 rs137854488 rs11687611 rs137854486 rs137854487 rs1250209 rs17449032 rs1250209 rs1373375768 |
Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:29100092}. |
Mouse PG classification | NA |
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