| Gene Information | |
|---|---|
| Gene Name | SLITRK6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 841 |
| Protein Names | SLIT and NTRK-like protein 6 |
| Target Name | slit and ntrk-like family member 6 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000184564 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H5Y7 |
| Gene Card | SLITRK6 |
| Uniprot ID | Q9H5Y7 |
| Pfam | PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-0.507334499) |
| Ortholog in Animals | Alpaca_ SLITRK6 ( ortholog_one2one ) Macaque_ SLITRK6 ( ortholog_one2one ) Mouse_ Slitrk6 ( ortholog_one2one ) Pig_ SLITRK6 ( ortholog_one2one ) Rat_ Slitrk6 ( ortholog_one2one ) Rabbit_ SLITRK6 ( ortholog_one2one ) |
| Ohnologs | SLITRK4, SLITRK2, SLITRK3 |
| Paralogs | TLR9, LRRC70, LRFN2, LRFN5, SLITRK3, LRFN4, GP5, SLITRK2, LINGO1, TPBGL, LRFN1, LRRN1, SLITRK1, LRTM2, SLIT3, LRRN2, LRRN3, SLIT2, LRRC38, SLITRK4, LINGO2, SLIT1, SLITRK5, LRRC55, LRFN3 |
| Tissue | NA |
| Tissue Specificity | In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors. {ECO:0000269|PubMed:14557068}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12863734 rs9547378 rs17080147 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23543054, ECO:0000269|PubMed:23946138}; Single-pass type I membrane protein {ECO:0000269|PubMed:23543054, ECO:0000269|PubMed:23946138}. |
| Mouse PG classification | LPG |
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