| Gene Information | |
|---|---|
| Gene Name | FMNL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1100 |
| Protein Names | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000184922 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95466 |
| Gene Card | FMNL1 |
| Uniprot ID | O95466 |
| Pfam | PF06367; PF06371; PF02181 |
| In ASD | no |
| Allosteric Prediction | no (-0.580821872) |
| Ortholog in Animals | Alpaca_ FMNL1 ( ortholog_one2one ) Dog_ FMNL1 ( ortholog_one2one ) GuineaPig_ FMNL1 ( ortholog_one2one ) Macaque_ FMNL1 ( ortholog_one2one ) Mouse_ Fmnl1 ( ortholog_one2one ) Pig_ FMNL1 ( ortholog_one2one ) Rat_ Fmnl1 ( ortholog_one2one ) |
| Ohnologs | FMNL2, FMNL3 |
| Paralogs | FHOD3, FHOD1, FHDC1, GRID2IP, FAM47B, DAAM2, FNBP4, SHTN1, FAM47C, FAM47A, DAAM1, DIAPH3, DIAPH2, FMN2, FMNL3, FMNL2, INF2, DIAPH1 |
| Tissue | adipose.tissue, spleen |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YDH (X-ray 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19815554}; Lipid-anchor {ECO:0000269|PubMed:19815554}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). {ECO:0000250}.; [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions. |
| Mouse PG classification | NA |
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