| Gene Information | |
|---|---|
| Gene Name | FMN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1722 |
| Protein Names | Formin-2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000155816 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZ56 |
| Gene Card | FMN2 |
| Uniprot ID | Q9NZ56 |
| Pfam | PF02181 |
| In ASD | no |
| Allosteric Prediction | no (-0.623059612) |
| Ortholog in Animals | Macaque_ FMN2 ( ortholog_one2one ) Mouse_ Fmn2 ( ortholog_one2one ) Rat_ AABR07021812.1 ( ortholog_one2one ) Rabbit_ FMN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FHOD3, FHOD1, FHDC1, GRID2IP, FAM47B, DAAM2, FNBP4, SHTN1, FAM47C, FAM47A, FMNL1, DAAM1, DIAPH3, DIAPH2, FMNL3, FMNL2, INF2, DIAPH1 |
| Tissue | brain |
| Tissue Specificity | Expressed almost exclusively in the developing and mature central nervous system. {ECO:0000269|PubMed:10781961}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YLE (X-ray 1.80A ) 3R7G (X-ray 2.20A ) |
| DBSNP | rs12732924 rs12732924 rs3795677 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20082305}. Cytoplasm, cytosol {ECO:0000269|PubMed:20082305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9JL04}. Nucleus {ECO:0000269|PubMed:26287480}. Nucleus, nucleolus {ECO:0000269|PubMed:23375502}. Cell membrane {ECO:0000250|UniProtKB:Q9JL04}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JL04}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JL04}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL04}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JL04}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JL04}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9JL04}. Note=Colocalizes with the actin cytoskeleton (PubMed:20082305). Recruited to the membranes via its interaction with SPIRE1 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Accumulates in the nucleus following DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:20082305, ECO:0000269|PubMed:26287480}. |
| Mouse PG classification | LPG |
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