| Gene Information | |
|---|---|
| Gene Name | FLT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1363 |
| Protein Names | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) |
| Target Name | vascular endothelial growth factor receptor 3 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000037280 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35916 |
| Gene Card | FLT4 |
| Uniprot ID | P35916 |
| Pfam | PF07679; PF07714; PF17988 |
| In ASD | no |
| Allosteric Prediction | no (-0.000641502) |
| Ortholog in Animals | Alpaca_ FLT4 ( ortholog_one2one ) GuineaPig_ FLT4 ( ortholog_one2one ) Macaque_ FLT4 ( ortholog_one2one ) Mouse_ Flt4 ( ortholog_one2one ) Pig_ FLT4 ( ortholog_one2one ) Rat_ Flt4 ( ortholog_one2one ) Rabbit_ FLT4 ( ortholog_one2one ) |
| Ohnologs | KDR, PDGFRA |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | breast, left.atrium, lung, lymph.node, placenta, tricuspid.valve, vagina |
| Tissue Specificity | Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. {ECO:0000269|PubMed:1327515, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:7675451}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003390(Rat);0.053846(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4BSJ (X-ray 2.50A ) 4BSK (X-ray 4.20A ) |
| DBSNP | rs34221241 rs372947534 rs307826 rs35874891 rs55667289 rs121909657 rs267606818 rs35171798 rs121909654 rs448012 rs34255532 rs56082504 rs121909653 rs121909650 rs121909651 rs56310180 rs1400220848 rs121909655 rs121909656 rs121909652 rs1130379 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:7898938}; Single-pass type I membrane protein. Cytoplasm {ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:20445537}. Nucleus {ECO:0000269|PubMed:16452200}. Note=Ligand-mediated autophosphorylation leads to rapid internalization. {ECO:0000269|PubMed:20445537}.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Cytoplasm. |
| Mouse PG classification | HPG |
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