| Gene Information | |
|---|---|
| Gene Name | FLT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 993 |
| Protein Names | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) |
| Target Name | fms-like tyrosine kinase 3 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000122025 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P36888 |
| Gene Card | FLT3 |
| Uniprot ID | P36888 |
| Pfam | PF00047; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.201310543) |
| Ortholog in Animals | Alpaca_ FLT3 ( ortholog_one2one ) Dog_ FLT3 ( ortholog_one2one ) GuineaPig_ FLT3 ( ortholog_one2one ) Macaque_ FLT3 ( ortholog_one2one ) Mouse_ Flt3 ( ortholog_one2one ) Pig_ FLT3 ( ortholog_one2one ) Rat_ Flt3 ( ortholog_one2one ) Rabbit_ FLT3 ( ortholog_one2one ) |
| Ohnologs | PDGFRB, PDGFRA, KIT, CSF1R |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia. {ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:7507245, ECO:0000269|PubMed:8394751, ECO:0000269|PubMed:8637232}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1RJB (X-ray 2.10A ) 3QS7 (X-ray 4.30A ) 3QS9 (X-ray 7.80A ) 4RT7 (X-ray 3.10A ) 4XUF (X-ray 3.20A ) 5X02 (X-ray 2.40A ) 6IL3 (X-ray 2.50A ) 6JQR (X-ray 2.20A ) |
| DBSNP | rs12872889 rs56321896 rs146030737 rs1933437 rs35602083 rs34172843 rs56090538 rs35958982 rs121913487 rs121913488 rs121913488 rs121909646 rs121913488 rs121913232 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation. |
| Mouse PG classification | NA |
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