Gene Information
Gene NameFLT2
OrganismHomo sapiens (Human)
Gene Length822
Protein NamesFibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP11362
Gene CardFGFR1
Uniprot IDP11362
PfamPF07679; PF00047; PF07714
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. {ECO:0000269|PubMed:1652059}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AGW  (X-ray  2.40A  1CVS  (X-ray  2.80A  1EVT  (X-ray  2.80A  1FGI  (X-ray  2.50A  1FGK  (X-ray  2.00A  1FQ9  (X-ray  3.00A  1XR0  (NMR  2CR3  (NMR  2FGI  (X-ray  2.50A  3C4F  (X-ray  2.07A  3DPK  (X-ray  1.95A  3GQI  (X-ray  2.50A  3GQL  (X-ray  2.80A  3JS2  (X-ray  2.20A  3KRJ  (X-ray  2.10A  3KRL  (X-ray  2.40A  3KXX  (X-ray  3.20A  3KY2  (X-ray  2.70A  3OJV  (X-ray  2.60A  3RHX  (X-ray  2.01A  3TT0  (X-ray  2.80A  4F63  (X-ray  2.55A  4F64  (X-ray  2.05A  4F65  (X-ray  2.26A  4NK9  (X-ray  2.57A  4NKA  (X-ray  2.19A  4NKS  (X-ray  2.50A  4RWI  (X-ray  2.29A  4RWJ  (X-ray  2.49A  4RWK  (X-ray  2.98A  4RWL  (X-ray  2.19A  4UWB  (X-ray  2.31A  4UWC  (X-ray  1.96A  4UWY  (X-ray  2.31A  4V01  (X-ray  2.33A  4V04  (X-ray  2.12A  4V05  (X-ray  2.57A  4WUN  (X-ray  1.65A  4ZSA  (X-ray  2.00A  5A46  (X-ray  2.63A  5A4C  (X-ray  2.09A  5AM6  (X-ray  1.96A  5AM7  (X-ray  1.96A  5B7V  (X-ray  2.15A  5EW8  (X-ray  1.63A  5FLF  (X-ray  2.58A  5O49  (X-ray  1.91A  5O4A  (X-ray  2.01A  5UQ0  (X-ray  2.30A  5UR1  (X-ray  2.20A  5VND  (X-ray  2.20A  5W21  (X-ray  3.00A  5W59  (X-ray  2.50A  5Z0S  (X-ray  2.45A  5ZV2  (X-ray  2.86A  6C18  (X-ray  2.30A  6C19  (X-ray  2.12A  6C1B  (X-ray  2.00A  6C1C  (X-ray  2.15A  6C1O  (X-ray  2.29A  6ITJ  (X-ray  1.99A  6MZQ  (X-ray  2.00A  6MZW  (X-ray  2.20A  6NVL  (X-ray  2.70A  6P68  (X-ray  2.90A  6P69  (X-ray  2.20A  7OZB  (X-ray  1.71A  7OZD  (X-ray  1.82A  7OZF  (X-ray  1.82A 
DBSNP rs760884357  rs17175750  rs121909640  rs140254426  rs767195580  rs1554570706  rs727505373  rs55642501  rs747842199  rs780765366  rs121913473  rs765615419  rs397515481  rs121909630  rs869025669  rs17851623  rs121909635  rs121909645  rs121909627  rs121913472  rs1131691929  rs727505369  rs121909633  rs121909632  rs121909638  rs886037634  rs121909641  rs121909631  rs121909634  rs121909637  rs397515444  rs869025670  rs749758370  rs779707422  rs121909629  rs121909628  rs398122946  rs869025671  rs869025672  rs869320694  rs1563433902  rs397515446  rs727505376  rs397515445  rs768957161  rs1085307879  rs267606805  rs121909642  rs267606806  rs398122945  rs121909644  rs2956723  rs56234888  rs781328162  rs17182456  rs17182463 
Subcellular location [CC]Cell membrane;
Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Mouse PG classificationNA
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