Gene Information
Gene NameFLT
OrganismHomo sapiens (Human)
Gene Length1338
Protein NamesVascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP17948
Gene CardFLT1
Uniprot IDP17948
PfamPF07679; PF00047; PF07714; PF17988
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC). {ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:20512933}.
Pharmacological Animal Models0.020572(Chimpanzee);0.024788(Mouse);0.002419(Rat);0.050000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1FLT  (X-ray  1.70A  )  1QSV  (NMR  -  )  1QSZ  (NMR  -  )  1QTY  (X-ray  2.70A  )  1RV6  (X-ray  2.45A  )  2XAC  (X-ray  2.71A  )  3HNG  (X-ray  2.70A  )  4CKV  (X-ray  2.06A  )  4CL7  (X-ray  2.00A  )  5ABD  (X-ray  2.00A  )  5EX3  (X-ray  2.41A  )  5T89  (X-ray  4.00A  ) 
DBSNP rs56409818  rs35073261  rs55974987  rs55687105  rs553261958  rs35549791  rs35832528 
Subcellular location [CC][Isoform 1]: Cell membrane;
Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.;
[Isoform 2]: Secreted {ECO:0000269|PubMed:8248162}.;
[Isoform 3]: Secreted.;
[Isoform 4]: Secreted.;
[Isoform 5]: Cytoplasm {ECO:0000305}.;
[Isoform 6]: Cytoplasm {ECO:0000305}.;
[Isoform 7]: Cytoplasm {ECO:0000305}.
Mouse PG classificationNA
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