| Gene Information | |
|---|---|
| Gene Name | SPTB |
| Organism | Homo sapiens (Human) |
| Gene Length | 2137 |
| Protein Names | Spectrin beta chain, erythrocytic (Beta-I spectrin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000070182 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P11277 |
| Gene Card | SPTB |
| Uniprot ID | P11277 |
| Pfam | PF00307; PF00435 |
| In ASD | no |
| Allosteric Prediction | yes (0.358015657) |
| Ortholog in Animals | Alpaca_ SPTB ( ortholog_one2one ) Dog_ SPTB ( ortholog_one2one ) GuineaPig_ SPTB ( ortholog_one2one ) Macaque_ SPTB ( ortholog_one2one ) Mouse_ Sptb ( ortholog_one2one ) Pig_ SPTB ( ortholog_one2one ) Rat_ Sptb ( ortholog_one2one ) Rabbit_ SPTB ( ortholog_one2one ) |
| Ohnologs | SPTBN1, SPTBN2 |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4 |
| Tissue | bone.marrow, skeletal.muscle |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1S35 (X-ray 2.40A ) 3EDU (X-ray 2.10A ) 3F57 (X-ray 2.90A ) 3KBT (X-ray 2.75A ) 3KBU (X-ray 2.75A ) 3LBX (X-ray 2.80A ) |
| DBSNP | rs121918646 rs229587 rs55752508 rs3742601 rs77806 rs10132778 rs17180350 rs17245552 rs121918647 rs121918648 rs367841692 rs1225539653 rs121918649 rs121918645 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. |
| Mouse PG classification | HPG |
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