| Gene Information | |
|---|---|
| Gene Name | FLOT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 428 |
| Protein Names | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000132589 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q14254 |
| Gene Card | FLOT2 |
| Uniprot ID | Q14254 |
| Pfam | PF01145 |
| In ASD | no |
| Allosteric Prediction | yes (0.22600044) |
| Ortholog in Animals | Alpaca_ FLOT2 ( ortholog_one2one ) Dog_ FLOT2 ( ortholog_one2one ) GuineaPig_ FLOT2 ( ortholog_one2one ) Mouse_ Flot2 ( ortholog_one2one ) Pig_ FLOT2 ( ortholog_one2one ) Rat_ Flot2 ( ortholog_one2one ) Rabbit_ FLOT2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FLOT1 |
| Tissue | NA |
| Tissue Specificity | In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3736238 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Membrane-associated protein of caveolae. |
| Mouse PG classification | NA |
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