Gene Information
Gene NamePDZD3
OrganismHomo sapiens (Human)
Gene Length571
Protein NamesNa(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000172367 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ86UT5
Gene CardPDZD3
Uniprot IDQ86UT5
PfamPF00595; PF17820
In ASDno
Allosteric Predictionyes (0.140578661)
Ortholog in AnimalsAlpaca_ PDZD3 ( ortholog_one2one )
Dog_ PDZD3 ( ortholog_one2one )
GuineaPig_ PDZD3 ( ortholog_one2one )
Macaque_ PDZD3 ( ortholog_one2one )
Mouse_ Pdzd3 ( ortholog_one2one )
Pig_ PDZD3 ( ortholog_one2one )
Rat_ Pdzd3 ( ortholog_one2one )
Rabbit_ PDZD3 ( ortholog_one2one )
OhnologsPDZK1, PDZK1P1
ParalogsPDZK1, SLC9A3R1, SLC9A3R2
TissueNA
Tissue SpecificityExpressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. {ECO:0000269|PubMed:11950846}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2V90  (X-ray  2.00A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451};
Peripheral membrane protein {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}. Cytoplasm {ECO:0000269|PubMed:19088451}. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.
Mouse PG classificationNA
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