| Gene Information | |
|---|---|
| Gene Name | FLNC |
| Organism | Homo sapiens (Human) |
| Gene Length | 2725 |
| Protein Names | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000128591 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | FLNC |
| Uniprot ID | Q14315 |
| Pfam | PF00307; PF00630 |
| In ASD | no |
| Allosteric Prediction | yes (0.477985104) |
| Ortholog in Animals | Alpaca_ FLNC ( ortholog_one2one ) Dog_ FLNC ( ortholog_one2one ) GuineaPig_ FLNC ( ortholog_one2one ) Macaque_ FLNC ( ortholog_one2one ) Mouse_ Flnc ( ortholog_one2one ) Pig_ FLNC ( ortholog_one2one ) Rat_ Flnc ( ortholog_one2one ) Rabbit_ FLNC ( ortholog_one2one ) |
| Ohnologs | FLNA, FLNB |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, DTNA, SPTA1, DTNB, SPTBN4, FLNA |
| Tissue | heart, sigmoid.colon |
| Tissue Specificity | Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:7689010, ECO:0000269|PubMed:9791010}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1V05 (X-ray 1.43A ) 2D7M (NMR - ) 2D7N (NMR - ) 2D7O (NMR - ) 2D7P (NMR - ) 2D7Q (NMR - ) 2K9U (NMR - ) 2NQC (X-ray 2.05A ) 3V8O (X-ray 2.80A ) 4MGX (X-ray 3.16A ) 7OUU (X-ray 1.47A ) 7OUV (X-ray 1.80A ) 7P0E (X-ray 1.60A ) |
| DBSNP | rs1562991002 rs387906587 rs387906586 rs1562999443 rs2291569 rs2643766 rs2643767 rs879255639 rs374124083 rs1063261 rs879255640 rs1063262 rs200516164 rs2639142 rs2291572 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:25351925}. Membrane {ECO:0000269|PubMed:11038172}; Peripheral membrane protein {ECO:0000269|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert. |
| Mouse PG classification | NA |
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