| Gene Information | |
|---|---|
| Gene Name | FLNA |
| Organism | Homo sapiens (Human) |
| Gene Length | 2647 |
| Protein Names | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) |
| Target Name | filamin a |
| Target Type | Clinical trial target |
| Gene Age | 424 ( ENSG00000196924 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P21333 |
| Gene Card | FLNA |
| Uniprot ID | P21333 |
| Pfam | PF00307; PF00630 |
| In ASD | no |
| Allosteric Prediction | yes (1.353341765) |
| Ortholog in Animals | Alpaca_ FLNA ( ortholog_one2one ) Dog_ FLNA ( ortholog_one2one ) GuineaPig_ FLNA ( ortholog_one2one ) Macaque_ FLNA ( ortholog_one2one ) Mouse_ Flna ( ortholog_one2one ) Pig_ FLNA ( ortholog_one2one ) Rat_ Flna ( ortholog_one2one ) Rabbit_ RA_m006_jsm7BED4f ( ortholog_one2many ) |
| Ohnologs | FLNC, FLNB |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, DTNA, SPTA1, DTNB, SPTBN4, FLNC |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018868(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2AAV (NMR - ) 2BP3 (X-ray 2.32A ) 2BRQ (X-ray 2.10A ) 2J3S (X-ray 2.50A ) 2JF1 (X-ray 2.20A ) 2K3T (NMR - ) 2K7P (NMR - ) 2K7Q (NMR - ) 2MTP (NMR - ) 2W0P (X-ray 1.90A ) 2WFN (X-ray 3.20A ) 3CNK (X-ray 1.65A ) 3HOC (X-ray 2.30A ) 3HOP (X-ray 2.30A ) 3HOR (X-ray 2.70A ) 3ISW (X-ray 2.80A ) 3RGH (X-ray 2.44A ) 4M9P (X-ray 1.72A ) 4P3W (X-ray 2.00A ) 5XR1 (NMR - ) 6D8C (EM 3.54A ) 6EW1 (X-ray 2.31A ) |
| DBSNP | rs137853313 rs28935169 rs137853315 rs863223628 rs137853317 rs137853314 rs28935469 rs137853318 rs28935470 rs267606816 rs1064816 rs1064817 rs36051194 rs143873938 rs730319 rs782611953 rs267606815 rs137853311 rs267606817 rs17091204 rs28935471 rs80338837 rs137853312 rs28935472 rs28935473 rs137853319 rs35504556 rs137853316 rs57108893 rs368750879 rs727503930 |
| Subcellular location [CC] | Cytoplasm, cell cortex {ECO:0000269|PubMed:16291724}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BTM8}. Perikaryon {ECO:0000250|UniProtKB:Q8BTM8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8BTM8}. Note=Colocalizes with CPMR1 in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:Q8BTM8}. |
| Mouse PG classification | NA |
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