| Gene Information | |
|---|---|
| Gene Name | FLN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2602 |
| Protein Names | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75369 |
| Gene Card | FLNB |
| Uniprot ID | O75369 |
| Pfam | PF00307; PF00630 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. {ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:8327473, ECO:0000269|PubMed:9651345, ECO:0000269|PubMed:9694715}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DI8 (NMR - ) 2DI9 (NMR - ) 2DIA (NMR - ) 2DIB (NMR - ) 2DIC (NMR - ) 2DJ4 (NMR - ) 2DLG (NMR - ) 2DMB (NMR - ) 2DMC (NMR - ) 2E9I (NMR - ) 2E9J (NMR - ) 2EE6 (NMR - ) 2EE9 (NMR - ) 2EEA (NMR - ) 2EEB (NMR - ) 2EEC (NMR - ) 2EED (NMR - ) 2WA5 (X-ray 1.90A ) 2WA6 (X-ray 1.95A ) 2WA7 (X-ray 1.85A ) 3FER (X-ray 2.40A ) 4B7L (X-ray 2.05A ) 5DCP (X-ray 2.49A ) |
| DBSNP | rs80356506 rs80356504 rs80356494 rs121908894 rs121908895 rs80356508 rs80356507 rs121908896 rs80356509 rs80356510 rs150747960 rs28937587 rs2276742 rs1131356 rs17058845 rs80356511 rs12632456 rs80356512 rs80356513 rs80356514 rs80356515 rs80356503 rs80356516 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line. Note=In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber. In differentiated tubes, isoform 1 is also detected within the Z-lines.; [Isoform 2]: Cytoplasm, cytoskeleton, stress fiber.; [Isoform 3]: Cytoplasm, cytoskeleton, stress fiber.; [Isoform 6]: Cytoplasm, cytoskeleton. Note=Polarized at the periphery of myotubes. |
| Mouse PG classification | NA |
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